期刊论文Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications复制

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M Ye, S Feng, Z Xu, W He, C Liu, W Zhu
Metabolism, 2025
Elsevier
Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as an age-predominant syndrome characterized by diastolic dysfunction despite preserved systolic performance. In the aged myocardium, fatty acid oxidation capacity declines, while glycolytic flux increases; however, impaired pyruvate oxidation limits mitochondrial glucose oxidation, resulting in suboptimal ATP yield per oxygen molecule and worsening energetic inefficiency. Mitochondrial deficits, marked by reduced biogenesis, NAD depletion related to reduced …