Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum
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C Xie, Y Yuan, Y Wang, C Qi, W Wang, C An…
Current Obesity …, 2025
Springer
Abstract Purpose of Review Obesity-related metabolic disorders such as metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic syndrome (MetS), and type 2 diabetes mellitus (T2DM) have traditionally been treated as separate conditions. This review aims to present a unified conceptual framework in which these disorders are viewed as progressive stages within a continuous and dynamic process of metabolic dysfunction. The goal is to clarify the shared mechanisms underlying this progression and to explore the …
