Robust estimation of the 18F-flurpiridaz retention fraction for quantification of myocardial blood flow in CAD patients
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R DeKemp, KY Wu, N Kaps, J Lazewatsky…
2020
jnm.snmjournals.org
221 Objectives: 18F-flurpiridaz (FPZ) is a new PET perfusion tracer with close to 100% extraction fraction during the first-pass transit through the coronary circulation. High tracer extraction is ideal for accurate quantification of myocardial blood flow (MBF) but requires compartment modeling with dynamic PET imaging. Early washout during the first few minutes following tracer extraction, results in reduced retention and image contrast in the standard perfusion images. MBF estimation using these images with a net retention …
