Reference intervals in value-based laboratory medicine: a shift from single-point measurements to metabolic variation-based models
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A Coskun, M Plebani
Clinical Chemistry and Laboratory …, 2025
degruyterbrill.com
Laboratory data can be meaningful only when compared with reliable reference data; therefore, the estimation of reliable reference data is just as important as the accurate measurement of measurands in patient samples. Since analyte concentrations in the human body are influenced by both random variations (such as biological fluctuations) and systematic variations (such as physiological rhythms and age-related changes), the conventional model for estimating reference data–based solely on the statistical distribution …
