Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/7909558
其他信息:
PMID: 7909558
作者: F P Bymaster; D T Wong; C H Mitch; J S Ward; D O Calligaro; ...
摘要: Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-me thylpyridine)] was evaluated in vivo in rat brain for effects on neurotransmitter turnover and inhibition of ex vivo binding of muscarinic radioligands. Xanomeline produced dose-related increases in the metabolite of dopamine, dihydroxyphenylacetic acid (DOPAC), in striatum. The increases in striatal DOPAC levels produced by xanomeline were antagonized by the relatively selective M1 antagonist trihexyphenidyl, suggesting tha...
