Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry.
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K Braun, P Kuhl, M Bernd, B Kutscher
Die Pharmazie, 2001
europepmc.org
In this study stabilities of several LHRH antagonists against proteolytic enzymes are compared. For the enzymatic tests 15 proteases which differ in both substrate specificity and pH optimum were selected. The cyclic and two linear antagonists proved to be extraordinarily stable against the enzymes used over an incubation time of 50 h. Some degradation products were identified by high-performance liquid chromatography combined with mass spectrometry.
