Research progress on the role and mechanism in the change of cardiac structure and function of cardiac fibrosis in the elderly
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F Xiao, J Qi, S Ma, L Sun, Y Sun
Cardiology in Review, 2025
journals.lww.com
Heart failure is closely related to aging. Elderly patients with heart failure are often able to retain normal systolic function, manifested by left ventricular hypertrophy with decreased diastolic function. Relevant studies have shown that age-related cardiac fibrosis plays an important role in the pathogenesis of cardiac diastolic heart failure. Activation of fibroblasts in the heart, the acquisition of a pro-fibrotic phenotype, and age-dependent accumulation of collagen can lead to progressive increases in myocardial stiffness and impaired diastolic …

