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De novo Design of a Highly Specific Inhibitor of Integrin Αvβ6 for Pulmonary Fibrosis复制

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A Roy, L Shi, A Chang, X Dong, J Li, RV Winegar…
papers.ssrn.com
We describe the de novo design of hyperstable inhibitory proteins that bind to human αvβ6
with sub-nanomolar affinity and with> 1000x specificity over other RGD (Arg-Gly-Asp)-binding …

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