Metabolic engineering of Corynebacterium glutamicum for vitamin B12-independent production of 3-hydroxypropionic acid
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CW Moon, MR Ghiffary, CPS Prabowo, HU Kim…
Metabolic …, 2025
Elsevier
Hydroxypropionic acid (3-HP) is a versatile platform chemical with broad applications, serving as a precursor for the synthesis of value-added chemicals as well as the biodegradable polymers. However, current industrial production of 3-HP relies on chemical synthesis, which requires harmful raw materials and harsh reaction conditions. As a sustainable alternative, microbial biosynthesis of 3-HP has gained increasing attention. Yet, most reported pathways remain constrained by their dependence on vitamin B 12, a costly …
