Aldosterone: Synthesis and regulation.
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E Álvarez-García, M Bello-Rego
Vitamins and Hormones, 2025
europepmc.org
Aldosterone, the principal mineralocorticoid, is exclusively synthesized in the glomerular zone of the adrenal cortex. Its primary function is to maintain water and electrolyte balance and regulate blood pressure. The synthesis of aldosterone begins with the transport of cholesterol to the mitochondria, a process that is mediated by the StAR protein. This is followed by a sequence of reactions that are catalyzed by specific enzymes. CYP11A1, 3β-HSD2, CYP21A2, and finally CYP11B2. The regulation of its production is classified as …
