Sustainable Approaches in Solid-phase Oligonucleotide Synthesis: Current Status and Future Directions
1. 系统已在2026-02-09 10:57:58对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
YS Sanghvi, L Ferrazzano, W Cabri, A Tolomelli
2024
books.rsc.org
Solid-phase oligonucleotide synthesis (SPOS) using nucleoside phosphoramidites has been practiced since the early 1980s. 1 This protocol is exceedingly efficient in the assembly of monomeric amidite units in a sequential manner without the need for the isolation of intermediates after each step. Remarkably, the reproducibility, robustness, and high yields make the SPOS protocol a top choice for the production of all therapeutic oligonucleotides on the market and in clinical trials. In 2001, we summarized the applications of green …
