Sustainable Approaches in Solid-phase Oligonucleotide Synthesis: Current Status and Future Directions
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YS Sanghvi, L Ferrazzano, W Cabri, A Tolomelli
2024
books.rsc.org
Solid-phase oligonucleotide synthesis (SPOS) using nucleoside phosphoramidites has been practiced since the early 1980s. 1 This protocol is exceedingly efficient in the assembly of monomeric amidite units in a sequential manner without the need for the isolation of intermediates after each step. Remarkably, the reproducibility, robustness, and high yields make the SPOS protocol a top choice for the production of all therapeutic oligonucleotides on the market and in clinical trials. In 2001, we summarized the applications of green …
