Advancing biomolecular understanding and design following human instructions
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X Zhuang, K Ding, T Lyu, Y Jiang, X Li…
Nature Machine …, 2025
nature.com
Understanding and designing biomolecules, such as proteins and small molecules, is central to advancing drug discovery, synthetic biology and enzyme engineering. Recent breakthroughs in artificial intelligence have revolutionized biomolecular research, achieving remarkable accuracy in biomolecular prediction and design. However, a critical gap remains between artificial intelligence's computational capabilities and researchers' intuitive goals, particularly in using natural language to bridge complex tasks with human intentions. Large …