Bioavailability of glycyrrhizin and licorice extract in rat and human plasma as detected by a HPLC method
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8197226
其他信息:
PMID: 8197226
作者: M A Raggi; F Maffei; F Bugamelli; G Cantelli Forti; M A Raggi; ...
摘要: The pharmacokinetic behaviour of glycyrrhizin (1) was investigated in order to evaluate the difference in bioavailability after oral administration of licorice extract (LE) or glycyrrhizin (1) to rats and humans. For this study, two reliable HPLC methods were developed for the dosage of the levels of 1 and of its metabolite, the glycyrrhetic acid (2) in plasma samples. The determinations were carried out by HPLC on a reversed phase column with UV detector (251 nm), after a careful extraction ste...
