Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification
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S Yu, Y Cheng, C Pan, JT Yu
Organic & Biomolecular Chemistry, 2025
pubs.rsc.org
A photocatalytic radical cascade cyclization of N-acryloylhydrazides with α-bromoketones was developed. A series of 4-(3-oxo-3-phenylpropyl)-1H-pyrazol-5 (4H)-ones were formed in moderate to good yields. α-Bromo difluoroacetamides and 2-bromoacetonitrile were also suitable reaction partners. Late-stage modifications of several drug molecules were also achieved through our strategy.
