期刊论文Influence of estrogens on the androgen metabolism in different subunits of human hair follicles复制

DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/11358723复制

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PMID: 11358723
作者: S Niiyama; R Happle; R Hoffmann; S Niiyama; S Niiyama; ...
摘要: The molecular pathways involved in estrogen-mediated induction of hair growth in androgenetic alopecia are unknown. Some authors found that estradiol (E) inhibited 5alpha-reductase (5alpha-R) activity and therefore we addressed the question whether 17alpha- or 17beta-E are able to modulate the activity of 5alpha-R, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) or 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in isolated compartments of human hair follicles. For this purpose, scalp biopsies f...