Matrix metalloproteinase-12 (MMP-12) and its inhibitors: A mini-review
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JSD Tamang, S Banerjee, SK Baidya, S Das…
European Journal of …, 2024
Elsevier
Matrix metalloproteases (MMPs) are the proteolytic enzymes accountable for extracellular matrix (ECM) modification through their Zn2+-dependent catalytic activity. Among these, MMP-12 is one of the crucial MMPs that contributes to various disease states including different types of cancers and other major pathophysiological conditions including COPD, asthma, emphysema, skin diseases, arthritis, vascular diseases, and neurological disorders. The majority of the MMP-12 inhibitors should have three constitutional pharmacophoric …
