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Severe CPT-11-induced diarrhea in presence of FK-506 following liver transplantation for hepatocellular carcinoma.复制

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DOI:复制

文献链接: https://europepmc.org/article/med/11911319复制

其他信息:

JM Gornet, F Lokiec, JC Duclos-Vallee…
Anticancer …, 2001
europepmc.org
… We studied the clinical and pharmacological interactions between CPT-11 and FK506 in a
liver transplant patient. Serial plasma samples of FK506, CPT-11, SN-38 and SN-38
glucuronide were assayed by high-performance liquid chromatography. … While no CPT-11
toxicity was observed pre-operatively, several post-operative cycles of CPT-11 were
complicated with severe diarrhea. No change in FK506 plasma concentrations was noted in the …

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