Polarity-and Sequence-Dependent Ionization of Therapeutic Antibody–siRNA Conjugates: Enabling Intact Multi-attribute Method for Comprehensive …
1. 当前求助状态已完结, 请及时下载应助文件
2. 系统将在 2026-10-20 17:16:22 删除文件
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
H Liu, JL Veltri, PC Gough, SO Crowe…
Analytical …, 2026
pmc.ncbi.nlm.nih.gov
Antibody–siRNA conjugates (ARCs) represent a promising approach for delivering small interfering ribonucleic acids (siRNAs) to targeted cells, tissues, or organs. The complexity of the molecules poses great analytical challenges in identifying, characterizing, and monitoring their critical quality attributes (CQAs) during process development and manufacturing release. We developed a novel approach, intact multi-attribute method (iMAM), for ARC characterization using native size exclusion chromatography mass …
