Kv1. 3 expression on CD4 ( ) T cells promotes interleukin-17A-associated airway inflammation and airway remodeling in asthma
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B Sun, J Lin
Translational Research, 2025
Elsevier
Background Different types of T helper cells play an important role in disease severity and treatment response in patients with asthma. The potassium channel Kv1. 3 is a type of potentially therapeutic target in T-cell-mediated inflammatory diseases. Objective This study aimed to explore the potential of Kv1. 3 as a therapeutic target for asthma and to assess the efficacy of the Kv1. 3 inhibitor PAP-1 in the treatment of asthma. Methods Kv1. 3 expression on CD4 T cells was determined using data from public databases. CD4 T cells were …