IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity
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F Naz, MJ Uddin, N Hagspiel, MK Young, D Tyus…
The Journal of Clinical …, 2025
jci.org
Clostridioides difficile infection (CDI) recurs in 1 of 5 patients. Monoclonal antibodies targeting the virulence factor TcdB reduce disease recurrence, suggesting that an inadequate anti-TcdB response to CDI leads to recurrence. In patients with CDI, we discovered that IL-33 measured at diagnosis predicts future recurrence, leading us to test the role of IL-33 signaling in the induction of humoral immunity during CDI. Using a mouse recurrence model, IL-33 was demonstrated to be integral for anti-TcdB antibody production …
