Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agents
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KA Rodvold, JM George, L Yoo
Clinical pharmacokinetics, 2011
Springer
The exposure-response relationship of anti-infective agents at the site of infection is currently being re-examined. Epithelial lining fluid (ELF) has been suggested as the site (compartment) of antimicrobial activity against lung infections caused by extracellular pathogens. There have been an extensive number of studies conducted during the past 20 years to determine drug penetration into ELF and to compare plasma and ELF concentrations of anti-infective agents. The majority of these studies estimated ELF drug …
