铁右旋糖酐产品的开发与比较
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R Lawrence
PDA Journal of Pharmaceutical Science and …, 1998
journal.pda.org
Iron dextran complex has existed as a parenteral drug formulation for forty years. Two new formulations of this prodrug became available after an older form was withdrawn from distribution in the United States. Molecular weight, lot-to-lot consistency and thermal stability were examined among these three complex formulations using HP-GPC analysis. Also, particle size measurements using transmission electron microscopy and reduction degradation kinetics were determined. In each mode of analysis, substantial differences …
