General pharmacological studies on tramadol, a potent analgetic agent (author's transl)
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G Osterloh, E Friderichs, F Felgenhauer…
Arzneimittel …, 1978
europepmc.org
The general pharmacological properties of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal) are described and compared with those of other strong narcotic analgetics. In behavioral studies tramadol in high doses had a primarily stimulating effect in mice and rats and a sedative effect in rabbits and dogs. The Straub tail phenomenon, a reaction typical for mice administered morphine, was observed only after subtoxic doses of tramadol. In iv doses tramadol generally caused a weak central inhibition …
