Computational Fluid Dynamics Simulations of Single-Use Bioreactors for the Scale-Up of Cell Culture Processes
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D Kreitmayer
2022
archiv.ub.uni-heidelberg.de
Monoclonal antibodies are biomolecules that are able to bind to a specific antigen. Antibodies are important drugs for the targeted treatment of various types of cancer. Due to their complex molecular structure, monoclonal antibodies are usually produced through the cultivation of genetically modified mammalian cells. At the production scale, the cultivation is typically carried out using sparged stirred tank bioreactors and the product quality as well as the yield depend, among other factors, on the hydrodynamic conditions inside the utilized …
