Coordinated Reinforcement of Energy and Ammonia-Donor Supply Enhances L-Histidine Production in Escherichia coli
1. 请及时下载文件确认是否正确, 系统将在 2026-07-10 11:40:48 删除文件
2. 如若文件有误请驳回应助文件, 求助状态即回到求助中
3. 如若文件正确请及时点击确认, 若超过时后系统自动默认为已完结
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
ZY Chen, Q Sheng, X Dong, C Gao, XM Li, GP Hu…
Food Bioscience, 2026
Elsevier
L-histidine is a high-value amino acid widely used in the food, pharmaceutical, and additive industries. However, efficient production of L-histidine in Escherichia coli remains challenging because its biosynthesis requires substantial precursor, energy, and ammonia-donor supply. In this study, the L-histidine biosynthetic pathway and the pentose phosphate pathway were optimized to construct strain His20. During late-stage fermentation, elevating dissolved oxygen and supplementing monosodium glutamate or glutamine hydrochloride …
