Leveraging sequential and spatial neighbors information by using CNNs linked with GCNs for paratope prediction
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S Lu, Y Li, F Wang, X Nan…
IEEE/ACM Transactions on …, 2021
ieeexplore.ieee.org
Antibodies consisting of variable and constant regions, are a special type of proteins playing a vital role in immune system of the vertebrate. They have the remarkable ability to bind a large range of diverse antigens with extraordinary affinity and specificity. This malleability of binding makes antibodies an important class of biological drugs and biomarkers. In this article, we propose a method to identify which amino acid residues of an antibody directly interact with its associated antigen based on the features from sequence and structure. Our …
