Quantification of Active and Total Adalimumab using Affinity Purification Coupled with Tryptic Digestion-Based Liquid Chromatography-Tandem Mass Spectrometry …
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DOI:
文献链接: https://www.sciencedirect.com/science/article/abs/pii/S0731708525005230?dgcid=raven_sd_aip_email
其他信息:
X Hou, Y Liu, Z Cai, Y Chen, S Li, L Su, F Fang…
… of Pharmaceutical and …, 2025
Elsevier
Therapeutic drug monitoring is commonly employed to investigate the loss of response to adalimumab. However, existing methodologies focus exclusively on measuring active adalimumab, neglecting the presence of inactive forms, which may result in incomplete or misleading clinical evaluations. To address this limitation, a liquid chromatography-tandem mass spectrometry method incorporating affinity purification was developed for the simultaneous quantification of both active and total adalimumab concentrations in serum …
