New chapter in rabies vaccine development
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LG Visser
The Lancet Infectious Diseases, 2026
thelancet.com
It has been more than 200 years since Pasteur, Vulpian, and Grancher conducted the first successful human immunisation against rabies with a live-attenuated vaccine derived from dried rabid rabbit spinal cord material. The current modern purified cell culture and embryonated egg-derived rabies vaccines were developed between the 1960s and 1980s. These inactivated rabies vaccines are highly immunogenic, induce a robust and long-lasting B-cell memory, and are highly effective in preventing rabies. 1 However, the high costs and …
