期刊论文Next trip: a promising CK1α-selective molecular glue degrader in MSS colorectal cancer复制

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H Jo, H Choi, H Kim, S Park, Y Shin, H Shin…
Cancer …, 2025
aacrjournals.org
Casein kinase 1α (CK1α) is a serine/threonine kinase that plays a critical role in cellular homeostasis. In previous studies, CK1α promotes p53 inactivation by regulating MDM2 and MDMX, and this mechanism may represent a promising anticancer target Indeed, many studies have been reported recently on the development of CK1α inhibitors and degraders as anticancer agents. We recently developed PIN5018, a selective CK1α inhibitor, and reported that it exhibits promising anticancer activity in acute myeloid leukemia (AML) and …