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Real-World Safety Profile of Xanomeline-Trospium (Cobenfy), the First Muscarinic Agonist Antipsychotic: A Disproportionality Analysis of the FDA Adverse Event …复制

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H Farquhar
Available at SSRN 6611902
papers.ssrn.com
Background: Xanomeline-trospium (Cobenfy), the first antipsychotic with a non-dopaminergic mechanism approved in over 30 years, received FDA approval for schizophrenia in September 2024. Its muscarinic M1/M4 agonist mechanism may produce a different adverse event profile compared with conventional antipsychotics, but post-marketing data have not been comprehensively evaluated with active-comparator analyses. We aimed to characterise the safety profile of xanomeline-trospium using …

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