Pathophysiological mechanisms underlying MAFLD
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MS Kuchay, NS Choudhary, SK Mishra
Diabetes & Metabolic Syndrome …, 2020
Elsevier
Background and aims The pathophysiology underlying metabolic associated fatty liver disease (MAFLD) involves a multitude of interlinked processes, including insulin resistance (IR) underlying the metabolic syndrome, lipotoxicity attributable to the accumulation of toxic lipid species, infiltration of proinflammatory cells causing hepatic injury and ultimately leading to hepatic stellate cell (HSC) activation and fibrogenesis. The proximal processes, such as IR, lipid overload and lipotoxicity are relatively well established, but the downstream …
