Pharmacokinetics and metabolism of im injected polyenylphosphatidylcholine liposomes.
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/582734/
其他信息:
O Zierenberg, H Betzing
Arzneimittel-forschung, 1979
europepmc.org
The pharmacokinetics of im applied polyenylphosphatidylcholine liposomes has been investigated in rats with the aid of 3H-and 14C-labelled di-linoleoyl-sn-glycerophosphocholine. The experiments stated an efflux of polyenylphosphatidylcholine from muscle injection site with a half-life of 8.6 h. The analysis of remaining polyenylphosphatidylcholine at muscle injection site showed the great stability of this substance. After 24 h approximately 60% of remaining polyenylphosphatidylcholine are not …
