Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
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G Mountzios, L Sun, BC Cho, U Demirci…
… England Journal of …, 2025
Mass Medical Soc
Background Tarlatamab, a bispecific delta-like ligand 3–directed T-cell engager immunotherapy, received accelerated approval for the treatment of patients with previously treated small-cell lung cancer. Whether tarlatamab is more effective than chemotherapy in the treatment of patients whose small-cell lung cancer has progressed during or after initial platinum-based chemotherapy is not known. Methods We conducted a multinational, phase 3, open-label trial to compare tarlatamab with chemotherapy as second-line treatment in …