PET imaging of c-Met activity in NSCLC using 18F Labelled c-MET inhibitor
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Z Han, T Zhang, M Ke, L Qiao, Z Wu, Z Guan, Z Li, Z Wu…
2021
jnm.snmjournals.org
148 Objectives: c-Met is a receptor tyrosine kinase, implicating cellular processes including proliferation and apoptosis [1]. Abnormal activation of c-Met pathway plays an important role in tumorigenesis and progression in NSCLC (non-small cell lung cancer) and mediates acquired resistance to targeted therapy [2]. Nevertheless, lack of accurate detection methods for c-Met in NSCLC challenges the overall efficacy of c-Met targeted therapy. Over past decades, important progresses have been made in field of c-Met imaging [3]. However, they …
