Domain-Adapted Diffusion Model for PROTAC Linker Design Through the Lens of Density Ratio in Chemical Space
1. 系统已在2026-02-01 11:18:18对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
Z Song, Z Meng, JM Hernández-Lobato
Forty-second International …
openreview.net
Proteolysis-targeting chimeras (PROTACs) are a groundbreaking technology for targeted protein degradation, but designing effective linkers that connect two molecular fragments to form a drug-candidate PROTAC molecule remains a key challenge. While diffusion models show promise in molecular generation, current diffusion models for PROTAC linker design are typically trained on small molecule datasets, introducing distribution mismatches in the chemical space between small molecules and target PROTACs. Direct fine-tuning on limited …
