Effect of polyamines on DNase I activity
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C Seppi, C Balduini
ITALIAN JOURNAL OF BIOCHEMISTRY, 2007
iris.unipv.it
The biogenic polyamines putrescine, spermidine and spermine are the most prevalent polyamines in mammalian cells. They are involved in several biological processes one of which is to bind nucleic acid. It has been expected that this feature reduces accessibility to enzymes and in fact, in some experimental conditions, an inhibition of endonuclease activity is observed in DNA with the addition of polyamines [Pingoud, A et al.(1984) Biochemistry 23, 5697-Kuosmanen, M and Poso, H (1985) FEBS Lett. 179, 17-Baeza, I et al.(1987) …
