Complete Plasminogen Activator Inhibitor 1 Deficiency Synonyms: Complete PAI-1 Deficiency, Homozygous PAI-1 Deficiency
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M Heiman, S Gupta, M Lewandowska, AD Shapiro
europepmc.org
Untreated complete plasminogen activator inhibitor 1 (PAI-1) deficiency is characterized by mild-to-moderate bleeding, although in some instances bleeding can be life-threatening. Most commonly, delayed bleeding is associated with injury, trauma, or surgery; spontaneous bleeding does not occur. While males and females with complete PAI-1 deficiency are affected equally, females may present more frequently with clinical manifestations or earlier in life than males due to menorrhagia and postpartum hemorrhage. Fewer than ten families …
