Reconsidering KLK7's role in adipose inflammation
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Y Zhong, J Wei, R Jiang
Metabolism-Clinical and …, 2025
metabolismjournal.com
We read with great interest the study by Ribas-Latre et al.[1] exploring the role of KLK7 in visceral adipose tissue inflammation in obesity. Using a macrophage-specific KLK7 knockout mouse model and human adipose tissue data, the authors provide compelling evidence that KLK7 promotes immune cell infiltration and pro-inflammatory polarization, highlighting its potential as a therapeutic target for metabolic inflammation. We commend the authors for their rigorous experimental design and mechanistic exploration. However, we …
