Multitasking by exploitation of intracellular transport functions: the many faces of FcRn
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ES Ward, RJ Ober
Advances in immunology, 2009
Elsevier
Abstract The MHC Class I-related receptor, FcRn, transports antibodies of the immunoglobulin G (IgG) class within and across a diverse array of different cell types. Through this transport, FcRn serves multiple roles throughout adult life that extend well beyond its earlier defined function of transcytosing IgGs from mother to offspring. These roles include the maintenance of IgG levels and the delivery of antigen in the form of immune complexes to degradative compartments within cells. Recent studies have led to …
