期刊论文Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam.复制

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TP Pruss, H Stroissnig, S Radhofer-Welte…
Postgraduate medical …, 1990
europepmc.org
Lornoxicam is a new, highly potent antirheumatic agent which is an oxicam derivative. Although highly potent as a cyclo-oxygenase inhibitor, the compound does not cause inhibition of 5-lipoxygenase and does not appear to shunt arachidonic acid through this cascade. This powerful inhibition of cyclo-oxygenase has manifested itself as highly potent analgesic and anti-inflammatory effects in animal studies and also prevented the bone destruction which normally occurs in the adjuvant polyarthritic rat. To explain this finding …