期刊论文[Pharmacokinetic studies with 3H-labelled synthetic antifibrinolytics]复制

DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/6984512复制

其他信息:

PMID: 6984512
作者: M Richter; F Markwardt; H P Klöcking; M Richter; M Richter; ...
摘要: In rabbits and rats pharmacokinetic studies on the anti-fibrinolytics 4-aminomethylbenzoic acid (PAMBA), trans-4-aminomethylcyclohexane-1-carboxylic acid (AMCA), and epsilon-aminocaproic acid (EACA) were carried out using the tritium labelled compounds. Following i. v. administration of PAMBA and EACA in rabbits a two-phasic plasma level and following AMCA a three-phasic plasma level was found within 7 h. The rate constants beta of 0.34 h-1, 0.44 h-1, and 1.08 h-1 for EACA, PAMBA, and AMCA, resp...