Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease
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H Xu, R Cao, X Dong, R Ma, C Morisseau…
Journal of Medicinal …, 2025
ACS Publications
The treatment of inflammatory bowel disease (IBD) may rely on the comprehensive regulation of immune inflammatory factors to reach a favorable therapeutic effect. In the current study, we discovered a series of sEH inhibitors containing a squaryl sulfonamide scaffold that potently inhibited the primary proinflammatory signaling pathways of NF-κB. Especially, lead compounds A1 and A9 showed potent inhibitory activities against sEH (A1 and A9; hsEH IC50= 0.1 nM, msEH IC50= 0.1 nM). The compound A1 had medium …
