Tetrazole Motif in Antihypertensive Drug Discovery: Synthetic Strategies, Structure–Activity Relationships, and Translational Perspectives (2010–2025)
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S Umarani, G Bannimath
ChemistrySelect, 2026
Wiley Online Library
Over the past decade, tetrazole derivatives have emerged as essential pharmacophores for mechanism‐based antihypertensive therapies, owing to their unique bioisosteric and electronic features. This review highlights progress from 2010 to 2025, focusing on tetrazole‐based agents as bioisosteric alternatives to carboxylic acids, which enhance metabolic stability, lipophilicity, and receptor affinity. Major angiotensin II receptor blockers—losartan, candesartan, and irbesartan—illustrate their clinical impact on efficacy and tolerability …
