Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications
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AL Klibanov
Investigative radiology, 2006
journals.lww.com
The use of microbubble contrast agents for general tissue delineation and perfusion enjoys steady interest in ultrasound imaging. Microbubbles as contrast materials require a small dosage and show excellent detection sensitivity. Targeting ligands on the surface of microbubbles permit the selective accumulation of these particles in the areas of interest, which show an up-regulated level of receptor molecules on vascular endothelium. Selective contrast imaging of inflammation, ischemia–reperfusion injury, angiogenesis, and …
