Beyond Exercise and Appetite: The Expanding Biology and Therapeutic Potential of Lac-Phe
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OP Oni, B Scott, LC Schwartz, TJ MacCormack…
… Therapeutics, 2025
Elsevier
Abstract N-lactoyl-phenylalanine (Lac-Phe) has emerged as a signaling metabolite connecting cellular metabolism to systemic physiology. Synthesized through carnosine dipeptidase 2 (CNDP2)-mediated conjugation of lactate and phenylalanine, Lac-Phe increases acutely in response to exercise and feeding, the primary drivers of its elevation under physiological conditions. In preclinical models, Lac-Phe acts as a potent regulator of energy balance. Its administration suppresses appetite and reduces body weight in obesity …
