Drug Metabolism
1. 系统已在2026-05-01 14:52:10对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
R Lock, PJH Webborn, CW Vose, RMJ Ings
2023
books.rsc.org
It is almost impossible to design a bioavailable, long half-life and safe drug without a good understanding of both the principles of, and specific risks associated with, drug metabolism. Designing potent compounds with limited metabolic liabilities has proven to be one of the key challenges of drug discovery. The reasons for this, and some potential solutions, are explored in this chapter. The issues described also include the propensity for rapid metabolism, the risks associated with reactive metabolites and the origins of metabolically …
