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… : A first-in-class TAU-1-directed androgen receptor (AR) and AR-V7 degrader recruits DDB1-CUL4-RBX1 E3 ligase to eliminate AR signaling in lethal prostate cancer复制

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MK Naidoo, C Au, KK Sahu, P Giannakakou
Cancer Research, 2026
aacrjournals.org
… TAU-1-directed N-terminal AR degrader that induces coordinated proteasomal elimination
of both AR and AR-V7… a novel chemotype capable of degrading both AR species. Medicinal …

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