Efficacy and safety of xanomeline-trospium chloride in schizophrenia: a randomized clinical trial
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I Kaul, S Sawchak, DP Walling, CA Tamminga…
JAMA …, 2024
jamanetwork.com
Importance A significant need exists for new antipsychotic medications with different mechanisms of action, greater efficacy, and better tolerability than existing agents. Xanomeline is a dual M 1/M 4 preferring muscarinic receptor agonist with no direct D 2 dopamine receptor blocking activity. KarXT combines xanomeline with the peripheral muscarinic receptor antagonist trospium chloride with the goal of reducing adverse events due to xanomeline-related peripheral muscarinic receptor activation. In prior trials …
