Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline–trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double …
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I Kaul, S Sawchak, CU Correll, R Kakar, A Breier…
The Lancet, 2024
thelancet.com
Background New treatments with new mechanisms are urgently needed for people with schizophrenia. Xanomeline is a dual M 1 and M 4-preferring muscarinic receptor agonist that does not block D 2 dopamine receptors, unlike all currently approved treatments for schizophrenia. Xanomeline–trospium (KarXT) combines xanomeline with the peripherally restricted muscarinic receptor antagonist trospium chloride with the goal of ameliorating xanomeline-related adverse events associated with peripheral muscarinic receptors. The …
