Antitumor 2, 3-dihydro-2-(aryl)-4 (1H)-quinazolinone derivatives: Interactions with tubulin
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E Hamel, CM Lin, J Plowman, HK Wang, KH Lee…
Biochemical …, 1996
Elsevier
A series of derivatives of 2, 3-dihydro-2-(aryl)-4 (1H)-quinazolinone (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity derived from interactions with tubulin. Significant inhibition of tubulin assembly and of the binding of radiolabeled colchicine to tubulin was demonstrated with several of the compounds, particularly NSC 145669, 175635, and 175636. The DHQZ derivatives are structurally …
